Mighty Guy combines the overhead perspective of a run and gun with the gameplay of a beat 'em up. Your character has to fight their way through a desert, town, and mechanical area filled with machines, humans, and bugs to fight. You use punches or a jump kick to defeat enemies as you advance upward. Some enemies will drop guns that you can pick up to use for yourself, making the game play more like a conventional run and gun. Once you defeat the boss at the end, the game will loop back to the beginning and repeat until you run out of lives.